奥地利专利AT515791A4 blister

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专利摘要:
The invention relates to a blister strip which can be adhesively bonded to the skin and is formed from at least two films and has an applicator for applying a medium contained in the blister onto or into the skin, the blister strip comprising an upper film (2) which comprises at least one protuberance (2.1), wherein the lower surface (2.2) of the upper film (2) surrounding the protuberance (2.1) is adhesive and the blister strip has a lower film (3) which covers the lower surface of the blister strip and from the adhesive underside (2). 2.2) of the upper foil (2) can be deducted. In the protuberance (2.1) of the upper film (2), an applicator (1) is used, which separates the protuberance (2.1) into at least two sub-volumes, wherein the applicator (1) has at least one opening (1.2) connecting two sub-volumes wherein a partial volume lies between the applicator (1) and the lower foil (3) and wherein at least a partial volume is completely enclosed by the inner surface of the protuberance (2.1) and the applicator (1) and contains the medium.
公开号:AT515791A4
申请号:T50755/2014
申请日:2014-10-21
公开日:2015-12-15
发明作者:
申请人:Forstner Bernhard Dr；
IPC主号:

专利说明:

description
The invention relates to a blister strip for adhering to the skin, in particular for carrying out an allergy test.
A blister strip is a layer composite comprising at least two layers, wherein one or more cavities lie between the layers, wherein the cavities are designated as blisters. Blister strips are known, for example, as medicament-type packaging, wherein active ingredients are contained in the blisters in the form of pills, which can be pressed out of the blister. A blister strip consists of two films, the lower film is flat and the upper film dome-shaped dimensionally stable protuberances (dents, blisters) auf¬weist so that form voids between the films. By applying pressure to the dome of the upper foil, the lower foil breaks and the contents of the cavity emerge.
For performing allergy testing, skin-applicable test strips are known which contain in a capsule or cavity an allergen which is mostly present in a liquid or gel-like carrier substance. In these allergy tests, by opening or destroying the capsule or cavity, the allergen is brought into contact with the skin. It is known in the art to perform these allergy test strips as a blister strip. Blister strips are also known in the prior art which can be applied to the skin of the person to be tested.
The adhesive blister strips which contain liquid allergens are known to be manufactured according to the above-described construction of the medicament package. In use, the bottom foil is adhered to the skin. An applicator is attached to the inside of the dome of the upper foil, which is capable of puncturing the lower foil and, if necessary, penetrating slightly into the skin. The dome is at least partially filled with liquid, which emerges through the hole in the film and is thus intended to reach the skin. Blister strips according to this principle are shown, for example, in WO 8705200 A1 and US 2014276196 A1. The disadvantage of this structure is that the film has to be pierced with the applicator, which can result in irregular or unreliable application of the allergen, or entails the risk of parts of the film penetrating into the skin , It is disadvantageous that this structure allows only a virtually point-like introduction of the allergen and that a flow of the fluid between the skin and the film is possible with the risk of mixing.
In other adhesive blister strips it is known to provide the Al¬lergen as a gel, or to keep liquid in a saugfä¬higen substrate or the liquid by surface tension on the inside of the blister. Blister strips with this principle are shown, for example, in US4802493A, US4966159A and US2007276284A1. In this case, the lower film can be removed before attaching the blister strip without leakage of liquid. On the inside of the dome of the upper film, in turn, there may be an applicator with which the skin can be injured to a slight extent. A disadvantage is that the allergen must be present in absorbent substrate or as a gel, in addition there is the danger that after removing the film when handling the allergen is applied in a wrong place or the gel or the absorbent Sub¬ strat is contaminated with other allergens (for example, from other Blis-tern).
Furthermore, it is shown in US Pat. No. 5,099,857 A to provide an additional capsule in the blister below the applicator, which capsule is destroyed in order to release the test liquid.
The object underlying the invention is to provide a glued-on blister strip for allergy tests, which has a simple structure and which allows the use of liquid test substances, wherein an applicator is to be mounted in the blister, which is a controlled minor Injury to the skin allows, with the application of the applicator no film should be punctured. For solving the problem, it is proposed that the applicator be designed or arranged in the blister such that it separates the blister into two areas. The first region lies between the inside of the preferably dome-shaped protuberance of the upper film and the applicator and is referred to in sequence as liquid sreservoir. The second region lies between the applicator and the lower film and is referred to as a Aus¬pressreservoir. By the applicator the two areas are in the unopened state of the blister strip close separated from each other.
In order to apply the blister strip, the lower film is stripped from the strip, thus exposing the underside of the upper film, which is provided with a skin-compatible adhesive at least in the area around each blister. Now, the bottom side of the top film is adhered to the skin so that the ejection reservoir is now formed by the applicator, optionally by the sidewalls of the protuberance below the applicator and the skin. By applying a force to the dome of the blister, the liquid of the liquid reservoir is moved through an opening in the applicator into the ejection reservoir.
If, after the liquid reservoir has been pressed out, the force on the applicator is increased somewhat further, it is moved in the direction of the skin and, for example, surface pressure on the skin can be achieved by finger pressure and careful circular, massaging movement of the applicator in the form of scratches and penetration of the allergen liquid into the upper area ¬ten skin layers can be achieved.
Thereafter, the force is removed and the blister strip left on the skin for a few minutes to await a response of the body to the allergen before the blister strip is removed.
The invention is illustrated by means of drawings:
Fig. 1: shows a sectional view of the structure of an exemplary blister strip according to the invention.
2 shows a sectional view of an exemplary blister strip according to the invention after removal of the lower foil.
3 shows a sectional view of an exemplary blister strip according to the invention, which is glued to the skin with a blister applicator in the initial state and an applicator which has already been pressed in and thus the allergen liquid has been pressed out into the ejection reservoir.
4 shows a sectional view of an exemplary blister strip according to the invention, which is glued to the skin with a pressure-actuated applicator and subsequent skin penetration.
5 shows a sectional view of an exemplary inventive blister strip with alternative configurations.
FIG. 6 shows an exemplary blister strip according to the invention from above. FIG.
7: FIGS. 7a to 7d show a sectional view of an exemplary blister strip according to the invention in several steps of an exemplary production method.
8: FIGS. 8a to 8c show exemplary applicator tips according to the invention.
Insofar as in the description of the figures the directions above and below or upper and lower are used, this refers to the position of the blister strip in alignment with the surface to which the strip is applied in accordance with its intended use. Below or the bottom is therefore that side facing the said area lies.
In Fig. 1 the construction of a preferred blister strip according to the invention is shown, wherein two blisters are shown in cross-section, each blister being formed by a protuberance 2.1 of the top film 2, which preferably has a dome shape as shown. In each blister, an applicator 1 is attached, which adhered to the annular contact surface with the inside of the protuberance 2.1, or liquid-sealed. The protuberance 2.1 is thus divided by the applicator 1 into two areas. The applicator 1 has an opening 1.2, through which liquid can flow during the application of the blister strip.
The two areas are closely separated in the unopened state of the blister strip, which can be achieved, for example, by a sealing plug 4 which is adhesively bonded to the lower film 3 and can thus be removed therewith. This sealing plug 4 can, for example, only close the opening 1.2 or, as shown in the left-hand blister, the entire base area of the blister. This embodiment has the advantage that the sealing plug 4 can be used with little effort and no adhesive can enter the blister or the applicator tip 1.1 during the production of the blister strip.
The applicator 1 preferably has a disk shape, wherein the edge of the disk is slightly widened and projecting downwards from the disk to increase the contact area with the protuberance 2.1. The applicator tip 1.1 also protrudes downwards centrally from the applicator 1, the applicator tip 1.1 preferably projecting further down than the edge of the disc so that it comes into contact with the skin when the applicator 1 is pressed down in front of the edge of the disc Otherwise, the applicator 1 itself would have to be slightly deformable, preferably elastically deformable, so that its center and thus the applicator tip 1.1 can be moved somewhat downwards, when the edge of the disc is already in contact with the skin 7. The disc is preferably inserted such that below the disc the dome walls of the protuberance 2.1 form a boundary of the Aus¬pressreservoirs 6, so the lower end of the edge of the disc spaced from the bottom 2.2 of the film 2 is inserted into the protuberance 2.1. If the protuberance 2.1 has a dome shape, the surface with which the disc rests against the protuberance 2.1 preferably conforms to the shape of the dome, ie has a ring shape and an upward taper, so that the disc is approximately a conical disk or Kugelscheibeist.
The applicator tip 1.1 is the part of the applicator 1, which can be brought into contact with the skin 7 in order to be able to cause a slight lesion thereof. The applicator tip 1.1 in this case has one or more sharp or pointed elements or edges, with which the skin 7 can be scratched or scratched or punctually penetrated. The applicator tip 1.1 can be a hollow needle tip or a pricked needle tip or have several of these, or similar to abrasive paper, geometries that are multi-ruled or irregularly projecting from the surface. The sharp or pointed elements are preferably crown-shaped around the opening 1.2 of the applicator 1, which preferably runs centrally in the applicator tip 1.1. If the applicator tip 1.1 is a hollow needle, then the opening of the hollow needle can be the opening 1.2 of the applicator 1.
Three exemplary particularly preferred applicator tips 1.1 according to the invention are shown in FIGS. 8a, 8b, 8c. The applicator tip according to the invention was found especially for this application, but because of the advantageous embodiment it can also be used for other applications, for example for the advantageous improvement of known (allergy test) applicators. The applicator tip 1.1 according to the invention has at least one preferably central opening 1.2, and is embodied, for example, as a cylinder. At the side facing the skin 7 or the lower film 3, the applicator tip 1.1 has several sharp or pointed elements, which are preferably arranged in a circle around the opening 1.2. Particularly advantageous these elements are formed by hollow needle tips, which can absorb a small amount of liquid on application and can bring this into the skin 7, or can bring in delay after penetration of the uppermost skin layers by contact with the Al¬lergenflüssigkeit. As shown in Fig. 8, conventional obliquely cut hollow needles may be used as pointed elements, which may penetrate into the skin as far as they protrude from the applicator tip 1.1.
Preferably, the hollow or penetrator needles are not slanted horizontally, as shown in FIGS. 8b and 8c, in order to avoid deep penetration and thus to penetrate only the uppermost skin layer. The shape of the Penetratorna delspitze is particularly preferably concave, trough-shaped and can also be provided with a fine toothing on the circumference.
As shown in FIG. 8c, the applicator tip 1.1 itself may preferably have a trough-shaped or concave shape on the lower side, so that a larger amount of liquid may remain in the area between the pointed and sharp elements. This can be achieved, for example, by having the small opening 1.2 at the bottom end of a phase, rounding or countersinking to increase its diameter. Preferably, the applicator tip 1.1 is produced by injection molding, wherein preferably the pointed or sharp elements and / or the applicator 1 are also formed in the injection mold so that a ready-to-use applicator 1 is produced in one working step. If the pointed or sharp elements consist of a different material, such as the applicator tip 1.1, they are preferably inserted into the injection mold, so that during injection molding they are partially embedded in the material of the applicator tip. As shown in Fig. 2, the lower Fo¬lie 3 can be deducted, wherein the upper surface 3.1 of the lower film 3, which an¬liegt on the bottom 2.2 of the upper film 2, is designed as an adhesive protective film. In order for the sealing plug 4 to adhere to the lower film 3, the lower film 3 in the area of the sealing plug 4 can not be designed as an adhesive film. By peeling off the lower film 3 with the sealing plug 4, the adhesive underside 2.2 of the upper film 2 and the opening 1.2 of the applicator 1 are exposed. The liquid does not pass through the opening 1.2, as long as no pressure is exerted on the protuberance 2.1, because of the small opening 1.2 no air in the liquid reservoir 5eringen can.
Thus, during storage or handling of the unopened blister strip, the sealing plug 4 serves to prevent the liquid reservoir 5 from being emptied into the ejection reservoir 6 due to unintentional compression of the protuberance 2.1.
As shown in FIG. 3, the opened blister strip with the adhesive underside 2.2 of the upper film 2 is adhered to the skin 7, whereby a cavity sealed in the environment in the form of the pressure-exerting reservoir 6 is formed between the applicator 1 and the skin 6. As can be seen in the second blister of Figure 3, by compressing the protuberance 2.1, the volume of the liquid reservoir 5 can be reduced, whereby the liquid is forced through the opening 1.2 of the applicator 1 and enters the Auspressreservoir 6.
As shown in the second blister in FIG. 4, the applicator 1 can be brought into contact with the skin 7 by further compression of the protuberance 2.1. This takes place when the inside of the protuberance 2.1 rests against the applicator 1, or when the resistance of the liquid against the extrusion is higher than the resistance of the dome sidewalls, which limit the ejection reservoir 6 laterally below the applicator 1, against deformation , Due to the dome geometry, the compression of the upper flat dome cap, which limits the liquid reservoir 5, requires less force than the compression of the steep dome side walls below the applicator 1.
When the applicator tip 1.1 is in contact with the skin 7, the allergen can be introduced into the skin 7 by gently orbiting the blister. For this, the sharp or pointed elements of the applicator tip 1.1 penetrate something into the skin 7. By suitable design of the applicator tip 1.1, for example by the distance with which the sharp or pointed elements protrude from the applicator tip 1.1, it can be determined how deep or in which skin layer the allergens penetrate. The objective construction is also advantageous if the applicator 1 does not have any pointed or sharp elements, for example for performing epicutaneous tests.
Depending on the dimension of the blister, or depending on the amount of liquid in the liquid reservoir 5, it may be necessary to create a possibility to allow the air enclosed in the ejection reservoir 6 to escape, so that it does not press under the adhesive layer of the film 2 and thereby possibly unwanted, uncontrolled escape of liquid takes place. One possibility is to provide a predetermined breaking point, so that liquid can only escape laterally under the adhesive layer and thus reaches the environment and not into another blister. Another possibility would be to connect the squeezing reservoir 6 with an expandable volume, for example a second empty squeezed blister, or another separated volume lying between the protuberance 2.1 and the applicator 1, which is compressed in the initial state.
If the blister is very small in area (or the distance between two blisters is sufficiently large compared to the adhesive surface), or the volume of the liquid reservoir 5 is small compared to the volume of the Auspressreservoirs 6 can be dispensed with the provision of an air outlet.
Preferably, the volume of the liquid reservoir 5 is approximately one fifth of the volume of the Auspressreservoirs 6. The volume of the liquid reservoir 5 is preferably between 20 and 30 μΐ. In this case, the provision of an air outlet is not necessary, since the small change in volume of the Auspressreservoirs6 is compensated by introducing the liquid by the elastic Nachgie¬bigkeit the skin 7. During application, the volume of the squeezing reservoir 6 is also slightly reduced by bringing the tip 1.1 to the skin 8, or the slight overpressure in the squeezing reservoir 6 is slightly increased, which leads to a further curvature of the skin 7. Since the allergy test is usually performed on the forearm or on the back of the lying patient, a small trough is thus formed in the skin 7 in the center of the blister in which the fluid collects.
As an option, to compensate for the additional volume from the liquid reservoir 5, or the volume of the ejection reservoir 6 reduced by the depression of the applicator 1, as shown in FIG. 5, the adhesive application on the underside 2.2 of the upper film 2 may be slightly spaced from the blister. The bonding job in this case is formed by a double-sided adhesive film 2.3. As shown in Fig. 5, the blister strip may have an additional protective layer 8 which rests or is secured to the upper surface of the upper film 2. This protective layer 8, preferably made of cardboard or foamed plastic, has recesses for the blisters and protects the blisters from damage during storage or when adhering to the skin 7. The application is not hindered by the protective layer 8, since the blister is accessible through the opening in the protective layer 8. In Fig. 5 is also shown that even the lower film 3 can be deep-drawn in the region of the blister, so that even the Dichtungspfropfen 4 forms or. closes the opening 1.2 and / or the entire base of the blister.
The material for the applicator 1 is dimensionally stable Mate¬rial such as hard plastic, in particular transparent Hartplastik.Der applicator 1 is particularly preferably produced inexpensively by injection molding. The sharp or pointed elements of the applicator tip 1.1 can also be made of hard plastic and connected monolithically to the applicator 1. Diescharfen or pointed elements may also consist of metal, glass orother hard hard-edged material.
The upper foil 2 or the lower foil 3 can be a plastic or aluminum foil (in particular hard aluminum foil), or a laminate, ie a layer composite of several foils. The upper foil 2 or the protuberance 2.1 can preferably be designed to be transparent. The upper film 2 or the material of the protuberance 2.1 is plastically deformable, so that after removal of the compressive force from the protuberance 2.1 this remains in the deformed state. In an elastic Ausstül¬pung 2.1 this would return to its Aus¬gangsform after removal of the force back and so the liquid from the Auspress¬ reservoir 6 in the liquid reservoir 5 partially zurücksau¬gen, which may even be desirable for some applications. For the sidewalls of the protuberance 2.1, which are below the applicator 1, an elastic rebound may be desirable for the applicator tip 1.1 to move slightly away from the skin 7 after successful application, thus not contacting the sharp elements throughout the test time Skin 7 are. The same can be achieved with plastically deformable side walls if, after application by pulling on the applicator 1, this is moved somewhat away from the skin 7.
The production of a blister strip can, as illustrated in FIGS. 7a-7d, take place in the following steps: embossing (or deep drawing etc.) of the upper film 2, whereby it is permanently deformed to form the blisters. - As shown in Fig. 7a, the liquid is placed in the blister, the upper sheet 2 in this case has the bottom side up, so that the blister forms a trough. As shown in Fig. 7b, the applicator 1 is inserted in the blister. As shown in FIG. 7c, the opening 2.1 or the blister is closed with the sealing plug 4. Alternatively, the applicator 1 and the sealing plug 4 may be used in common. As shown in Fig. 7d, the blister strip is provided with the lower film 3 which covers the sealing plug 4 and the upper film 2. As further shown in FIG. 7d, the upper film 2 is joined to the annular surface of the applicator 1.1, for example by being pressed against the applicator 1; to this end, as shown, the outer surface of the applicator 1 can be a groove or another surface structure (For example, several wells, or more vertically and / or horizontally extending grooves), so that the upper film 2 is positively connected ver¬bunden with the applicator 1 (without gluing or welding). Alternatively, the upper film 2 can be welded to the applicator 1 by brief application of heat and pressure. The connection of the upper foil 2 to the applicator 1 can be effected at any time after insertion of the applicator 1.
In order to releasably bond the lower film 3 with the upper film 2, the upper film 2 may already be provided with an adhesive layer before the introduction of the liquid, or, for example, only after the sealing plug 4 has been used. The sealing plug 4 can also be provided with an adhesive layer, or at least one point-shaped adhesive application, before or even after insertion, or even after insertion. Preferably, the adhesive layer of the Dichtungspfropfens4 has a different composition than the adhesive layer of the upper
Foil 2, so that the adhesive layer of the sealing plug 4 adheres strongly to the adhesive protective layer of the lower film 3. Alternatively, the adhesive layer may be applied to the lower film 3 by slightly adhesively bonding it in the region of the underside 2.2 of the upper film 2 and thus becoming soluble Adhesive layer is connected. In the region of the sealing plugs 4, the lower film 2 is strongly adhered and thus insoluble in an adhesive layer.
The underside 2.2 of the film 2 and the underside of the plug 4 with adhesive are provided, for example, by coating or gluing a double-sided adhesive film. The double-sided adhesive film is highly adhesive in the direction of the upper film 2, skin-friendly and adhesive to a degree that the test can be carried out without causing great pain without pulling it off.
As an alternative to the described method, the liquid can be injected through the opening 1.2 of the applicator 1, after this has been inserted into the blister and glued to the blister. In this case, the applicator preferably has at least two openings 1.2, so that air can escape through the second opening when filling.
After application of the lower film 3, the blisters and the da¬rin arranged applicators 1 are packaged sterile and protected against Konta¬ mination. An advantage of the physical construction of the blister strip is that it can only be opened immediately before the application and no additional instrument has to be used. The allergy test strip is therefore storable and transportable and can be used by untrained personnel and even under hygienically precarious environmental conditions, without there being any increased risk of infection for the person being examined or the applicator.
Since the allergy test strip can be conveniently produced in mass production owing to the simple structure and is extremely easy and safe to use, it is outstandingly suitable for alergy rapid tests with a short time expenditure for the specialist or for self-application.
The blister strip has at least one blister containing an allergen. In addition, a blister may be present, which contains the liquid without allergen for performing the negative control and / or a blister with histamine for performing the positive control.
In addition, any number of additional blisters may be present, each containing an allergen to be tested. The blister strip may comprise a series of blisters, or two or more parallel rows of blisters. Preferably, the blister strip has a row of 8 blisters. For example, one person can be tested for 14 allergens with two differently fitted blister strips (including positive and negative tests), with one strip being applied to the inside of each forearm. The population of the blister strips may be adapted to the particular field of use (e.g., geographically, or under investigation for individual allergen groups, e.g., animals / trees / grasses ...).
The blister strip can be combined with an adhesive strip, which remains after removal of the blister strip on the skin and carries the respective marking of the substance contained in the blister, as shown in Fig. 6. The marking can also be affixed to the blister strip itself and be transmitted by hand, for example. A further possibility of the assignment would be to arrange two or more blisters at a characteristic distance from each other so that the position of the blister strip on the skin can be reconstructed from the position of, for example, increased distance, or a template can only be applied in one way and thus unambiguously can. Another possibility would be to place one or more blisters offset from the other blisters arranged in series.
By way of example and in no way concluding, it should be pointed to the following possible generalizations with respect to the preferred embodiment of the invention set forth in the description of the figures, which according to the invention should be included within the scope of the present invention.
The blister or the protuberance of the upper film may have a deviating from the dome shape, for example, be cylindrical or rectangular, or have a complex volume, which, for example, consists of a cavity with two or more Kup¬peln.
Instead of the sealing plug 4 or in addition, the applicator 1 may have a thin membrane which closes the opening 1.2 and tears when pressure is applied.
It is also conceivable that the applicator separates the blister into three or more subregions, which are dense against each other, and when a compound is opened, a connection is opened. By way of example, the allergen or an active substance may thus be present as a solid in one subarea and only be dissolved from another subarea directly during the application in the liquid. The medium that is contained in the first subarea, that is to say the liquid reservoir 5, can be a gel, fat or vaseline in addition to liquid.

权利要求:
Claims (20)
[1]
Claims 1. A blister strip which is adherable to the skin and comprises at least two films and an applicator for applying a medium contained in the blister and the substances contained in the medium to or into the skin, the blister strip comprising an upper film (2) which has at least one protuberance (2.1), wherein the underside (2.2) of the upper foil (2) surrounding the protuberance (2.1) is adhesive and the blister strip has a lower foil (3) which covers the lower surface of the Blister¬ stripe ens and from the adhesive bottom (2.2) of the upper film (2) can be deducted, characterized in that in the protuberance (2.1) of the upper film (2) an applicator (1) is inserted, which the protuberance ( 2.1) in at least two partial volumes, the applicator (1) has at least one opening (1.2) which connects two partial volumes, a partial volume between the applicator (1) and the lower F and at least a partial volume is completely enclosed by the inner surface of the protuberance (2.1) and the applicator (1) and contains the medium.
[2]
A blister strip according to claim 1, characterized in that at least one of the sheets is a laminate.
[3]
3. blister strip according to one of claims 1 to 2, characterized ge indicates that the protuberance (2.1) is a dome.
[4]
4. blister strip according to one of claims 1 to 3, characterized ge indicates that the applicator (1) has at least one sharp or sharp element which can be brought into contact with the skin in Kon¬takt.
[5]
5. blister strip according to one of claims 1 to 4, characterized ge indicates that the lower film (3) has a Dichtungspfropfen (4), which closes the opening (1.2) of the applicator (1).
[6]
A blister strip according to claim 5, characterized in that the sealing plug (4) is bonded to the lower film (3) in particular, or is formed by a protuberance of the lower film (3).
[7]
7. blister strip according to one of claims 5 to 6, characterized ge indicates that the sealing plug (4) closes the entire base surface of the protuberance (2.1) of the upper film (2).
[8]
Blister strip according to one of claims 1 to 7, characterized in that the applicator (1) is disk-shaped and rings around the edge of the disc with the inner wall of the protuberance (2.1) is connected, wherein the applicator (1) in the center of the disc a Applicator tip (1.1) projecting from the disc towards the lower foil (3), wherein in the applicator tip (1.1) at least one opening (1.2) extends through the applicator (1).
[9]
9. blister strip according to one of claims 1 to 7, characterized ge indicates that the applicator tip (1.1) one or more central openings (1.2), wherein annularly around the opening (1.2) sharp or pointed elements of the Appli¬katorspitze (1.1) towards the lower foil (3) or the skin (7).
[10]
10. blister strip according to one of claims 4 to 9, characterized ge indicates that at least one sharp or pointed Ele¬ment is a hollow needle.
[11]
11. blister strip according to one of claims 1 to 10, characterized in that the applicator (1) with the upper film (2) glued, welded or pressed.
[12]
12. blister strip according to one of claims 1 to 11, characterized in that the edge of the applicator (1) is designed struktu¬riert and the upper film (2) is positively pressed into this structure.
[13]
13. blister strip according to one of claims 8 to 12, characterized in that the edge region of the disc of the Applika¬tors (1) is made wider than the region of the disc between the edge and the applicator tip (1.1).
[14]
14. blister strip according to one of claims 8 to 13, characterized in that the applicator (1) is inserted into the protuberance (2.1), that the lower edge of the disc beab-stands to the adhesive underside (2.2) of the upper film (2 )lies.
[15]
15. blister strip according to one of claims 1 to 14, characterized in that the upper foil (2) consists of plastically deformable material.
[16]
16. blister strip according to one of claims 1 to 15, characterized in that the applicator (1) is a dimensionally stable Kör¬per and is formed in particular of hard plastic.
[17]
A blister strip according to any one of claims 1 to 16, characterized in that there is a vent opening in that part volume of the protuberance (2.1) which does not contain the medium, the vent opening leading to the environment and being closable, or a sealed one expansible volume opens.
[18]
18. blister strip according to one of claims 1 to 17, characterized in that the medium is a liquid.
[19]
19. Blister strip according to one of claims 1 to 18, characterized in that the medium contains an allergen.
[20]
A blister strip according to claim 19, characterized in that the blister strip comprises a plurality of blisters, each blister containing a medium, one containing only the medium, one containing additional histamine, and an arbitrary number of blisters with distinguishable allergens.

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DE1066329B|1959-10-01|Injection ampoule

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同族专利:

公开号 | 公开日

AT515791B1|2015-12-15|

CA2965369A1|2016-04-28|

CA2965369C|2021-01-05|

EA201790732A1|2017-09-29|

MY179639A|2020-11-11|

CN107072645A|2017-08-18|

US20190357840A1|2019-11-28|

AU2015336915B2|2020-06-11|

JP6672290B2|2020-03-25|

EA034295B1|2020-01-27|

HUE053555T2|2021-07-28|

EP3209224B1|2020-12-09|

CN107072645B|2020-10-09|

BR112017008241A2|2018-01-09|

US10390753B2|2019-08-27|

JP2017533019A|2017-11-09|

KR20170074930A|2017-06-30|

KR102238104B1|2021-04-09|

LT3209224T|2021-01-25|

MX2017005162A|2017-07-27|

US20170340263A1|2017-11-30|

EP3209224A1|2017-08-30|

PT3209224T|2021-02-15|

HRP20210387T1|2021-04-16|

AU2015336915A1|2017-05-18|

ES2848855T3|2021-08-12|

WO2016061600A1|2016-04-28|

PL3209224T3|2021-06-14|

DK3209224T3|2021-02-08|

SI3209224T1|2021-04-30|

引用文献:

公开号 | 申请日 | 公开日 | 申请人 | 专利标题

US2841138A|1957-03-11|1958-07-01|Ernest S V Laub|Allergy testing device|

US4966159A|1981-12-14|1990-10-30|Maganias Nicholas H|Allergy test strip|

WO1996032142A1|1995-04-12|1996-10-17|Hopp Robert B|Skin patch for use in contact immunotherapy|

US4205689A|1978-09-05|1980-06-03|Aller-Screen, Inc.|Allergy testing system|

US4237906A|1978-12-06|1980-12-09|Havstad Harold R|Antigen injection assembly|

IT1131784B|1980-07-30|1986-06-25|Alfa Romeo Spa|HOMOGENIZATION DEVICE OF THE MIXTURE SUCTIONED BY A C.I.MOTOR|

US4802493A|1981-12-14|1989-02-07|Maganias Nicholas H|Device and method for allergy testing|

US4473083A|1981-12-14|1984-09-25|Maganias Nicholas H|Device and method for allergy testing|

EP0261149A4|1986-03-06|1988-12-08|Wray Reginald Charles|Skin test kit.|

US5179959A|1986-04-18|1993-01-19|Henry Fishman|Allergy testing apparatus and method|

US5099857A|1987-05-29|1992-03-31|Northern Sydney Area Health Service|Medical testing device with calibrated indicia|

US5104620A|1990-07-30|1992-04-14|Wiley Fred R|Disposable allergy skin testing kit|

JP4030609B2|1995-03-31|2008-01-09|ジョンソン・アンド・ジョンソン・ビジョン・ケア・インコーポレイテッド|Contact lens packaging|

US20070276284A1|2002-08-27|2007-11-29|Drdc Limited|Skin test device|

FR2845267B1|2002-10-08|2004-12-31|Antialis|SKIN DIAGNOSTIC KIT FOR ATOPIA|

JP2005087520A|2003-09-18|2005-04-07|Terumo Corp|Liquid medicine injector|

KR101018406B1|2009-10-28|2011-02-28|김도위|Tester with needle for diagnosing skin condition of allergen|

US9445762B2|2012-08-30|2016-09-20|Mystic Pharmaceuticals, Inc.|Fully self-contained unit dose devices for allergy skin testing|

WO2014151811A1|2013-03-15|2014-09-25|Allergy Devices, Inc.|System and method for allergy testing|HUE049487T2|2015-08-21|2020-09-28|Prof Dr Claus Bachert Bvba|Device for performing an allergy test|

SI3599188T1|2018-07-26|2020-12-31|Uhlmann Pac-Systeme Gmbh & Co. Kg|Blister package for medical products and tool for producing the blister package|

法律状态:
2019-12-15| PC| Change of the owner|Owner name: ALLTEST GMBH, AT Effective date: 20191108 |

优先权:

申请号 | 申请日 | 专利标题

ATA50755/2014A|AT515791B1|2014-10-21|2014-10-21|blister|ATA50755/2014A| AT515791B1|2014-10-21|2014-10-21|blister|

BR112017008241-1A| BR112017008241A2|2014-10-21|2015-10-16|blister strip that can be attached to the skin|

LTEP15808318.8T| LT3209224T|2014-10-21|2015-10-16|Blister strip|

DK15808318.8T| DK3209224T3|2014-10-21|2015-10-16|BLISTER STRIP|

US15/520,988| US10390753B2|2014-10-21|2015-10-16|Blister strip|

PT158083188T| PT3209224T|2014-10-21|2015-10-16|Blister strip|

JP2017522426A| JP6672290B2|2014-10-21|2015-10-16|Blister strip|

CN201580056922.7A| CN107072645B|2014-10-21|2015-10-16|Blister strip|

KR1020177013433A| KR102238104B1|2014-10-21|2015-10-16|Blister strip|

MYPI2017000593A| MY179639A|2014-10-21|2015-10-16|Blister strip|

EA201790732A| EA034295B1|2014-10-21|2015-10-16|Blister strip|

PL15808318T| PL3209224T3|2014-10-21|2015-10-16|Blister strip|

PCT/AT2015/050258| WO2016061600A1|2014-10-21|2015-10-16|Blister strip|

MX2017005162A| MX2017005162A|2014-10-21|2015-10-16|Blister strip.|

EP15808318.8A| EP3209224B1|2014-10-21|2015-10-16|Blister strip|

CA2965369A| CA2965369C|2014-10-21|2015-10-16|Blister strip|

AU2015336915A| AU2015336915B2|2014-10-21|2015-10-16|Blister strip|

ES15808318T| ES2848855T3|2014-10-21|2015-10-16|Blister strip|

SI201531533T| SI3209224T1|2014-10-21|2015-10-16|Blister strip|

US16/532,516| US20190357840A1|2014-10-21|2019-08-06|Blister strip|

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